Jim Simons acquired 13.8 Million Novo Nordisk shares worth $1.78 Billion. It makes up 2.63% of their stock portfolio and is their biggest holding. The first Novo Nordisk trade was made in Q2 2013. Since then Jim Simons bought shares nineteen more times and sold shares on 23 occasions. The stake costed the investor $629 Million, netting the investor a gain of 183% so far.