Tweedy Browne acquired 3.45 Million Ionis Pharmaceuticals shares worth $135 Million. That's 6.29% of their entire equity portfolio (6th largest holding). The investor owns 2.34% of the outstanding Ionis Pharmaceuticals stock. The first Ionis Pharmaceuticals trade was made in Q1 2022. Since then Tweedy Browne bought shares one more times and sold shares on six occasions. The stake costed the investor $120 Million, netting the investor a gain of 12% so far.